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蛋白質間相互作用の制御を可能にするPepMetics技術

MEDCHEM NEWS, 35(2), 75-80 (2025) Hajime Takashima, Research and Development Department, PRISM BioLab Co., Ltd. www.jstage.jst.go.jp/article/medchem/35/2/35_75/_article/-char/en  
詳細はこちら

Rational Strategy for Designing Peptidomimetic Small Molecules Based on Cyclic Peptides Targeting Protein–Protein Interaction between CTLA-4 and B7-1

Pharmaceuticals 2022, 15(12), 1506
Tsuihiji, Kumiko; Honda, Eiji; Kojoh, Kanehisa; Katoh, Shizue; Taguri, Tomonori; Yoshimori, Atsushi; Takashima, Hajime
詳細はこちら

Development of low-molecular-weight compounds targeting the cancer-associated KLF5 transcription factor

ACS Medicinal Chemistry Letters, 13(4), 687-694 (2022)
Nakaya, Takeo; Aizawa, Kenichi; Taguchi, Yuki; Tsuji, Kentaro; Sekine, Sachi; Murakami, Kazuhiro; Kasai, Masaji; Nakano, Hirofumi; Kondoh, Yasumitsu; Dan, Shingo; Yoshimori, Atsushi; Kouji, Hiroyuki; Takehara, Dai; Suzuki, Toru; Osada, Hiroyuki; Marata, Masayuki; Tanaka, Akira; Nagai, Ryozo
詳細はこちら

Visualized and Quantitative Conformational Analysis of Peptidomimetics

ACS omega, 6(40), 26601-26612 (2021)
Takashima, Hajime; Yoshimori, Atsushi; Honda, Eiji; Taguri, Tomonori; Ozawa, Jun; Kasai, Masaji; Shuto,
Satoshi; Takehara, Dai
詳細はこちら

Generalized-ensemble method study: A helix-mimetic compound inhibits protein-protein interaction by long-range and short-range intermolecular interactions

Journal of Computational Chemistry, 42(14), 956-969 (2021)
Higo, Junichi; Takashima, Hajime; Fukunishi, Yoshifumi; Yoshimori, Atsushi
詳細はこちら

E7386, a selective inhibitor of the interaction between β-catenin and CBP, exerts antitumor activity in tumor models with activated canonical wnt signaling

Cancer Research, 81(4), 1052-1062 (2021)
Yamada, Kazuhiko; Hori, Yusaku; Inoue, Satoshi; Yamamoto, Yuji; Iso, Kentaro; Kamiyama, Hiroshi; Yamaguchi, Atsumi; Kimura, Takayuki; Uesugi, Mai; Ito, Junichi; Matsuki, Masahiro; Nakamoto, Kazutaka; Harada, Hitoshi; Yoneda, Naoki; Takemura, Atsushi; Kushida, Ikuo; Wakayama, Naomi; Kubara, Kenji; Kato, Yu; Semba, Taro; Yokoi, Akira; Matsukura, Masayuki; Odagami, Takenao; Iwata, Masao; Tsuruoka, Akihiko; Uenaka, Toshimitsu; Matsui, Junji; Matsushima, Tomohiro; Nomoto, Kenichi; Kouji, Hiroyuki; Owa, Takashi; Funahashi, Yasuhiro; Ozawa, Yoichi
詳細はこちら

Anti-tumor activity of the small molecule inhibitor PRI-724 against β-catenin-activated hepatocellular carcinoma

Anticancer Research, 40, 5211-5219 (2020)
Gabata, Ryosuke; Harada, Kenichi; Mizutani, Yuki; Ouchi, Hirofumi; Yoshimura, Kaori; Sato, Yasunori; Kitao, Azusa; Kimura, Kiminori; Kouji, Hiroyuki; Miyashita, Tomoharu; Tajima, Hidehiro; Ohta, Tetsuo
詳細はこちら

β-catenin signaling inhibitors ICG-001 and C-82 improve fibrosis in preclinical models of endometriosis

Scientific Reports, 9(1), 20056 (2019)
Hirakawa, Tomoko; Nasu, Kaei; Miyabe, Saori; Kouji, Hiroyuki; Katoh, Akira; Uemura, Naoto; Narahara, Hisashi
詳細はこちら

mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model

Pharmacology Biochemistry and Behavior, 176, 1-5 (2019)
Kawase, Haruki; Ago, Yukio; Naito, Megumi; Higuchi, Momoko; Hara, Yuta; Hasebe, Shigeru; Tsukada, Shinji; Kasai, Atsushi; Nakazawa, Takanobu; Mishina, Tadashi; Kouji, Hiroyuki; Takuma, Kazuhiro; Hashimoto, Hitoshi
詳細はこちら

The novel inhibitor PRI-724 for Wnt/β-catenin/CBP signaling ameliorates bleomycin-induced pulmonary fibrosis in mice

Experimental Lung Research, 45(7), 188-199 (2019)
Okazaki, Hiroyasu; Sato, Seidai; Koyama, Kazuya; Morizumi, Shun; Abe, Shuichi; Azuma, Momoyo; Chen, Yajuan; Goto, Hisatsugu; Aono, Yoshinori; Ogawa, Hirohisa; Kagawa, Kozo; Nishimura, Haruka; Kawano, Hiroshi; Toyoda, Yuko; Uehara, Hisanori; Kouji, Hiroyuki; Nishioka, Yasuhiko
詳細はこちら
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