{"id":1645,"date":"2023-01-13T15:53:41","date_gmt":"2023-01-13T20:53:41","guid":{"rendered":"https:\/\/prismbiolab.com\/?post_type=news&#038;p=1645"},"modified":"2023-01-18T04:46:13","modified_gmt":"2023-01-18T09:46:13","slug":"new-study-by-prism-biolab-demonstrates-rational-design-of-small-molecule-inhibitors-of-ctla-4-and-b7-1-protein-protein-interaction-utilizing-only-a-sequence-of-a-binding-peptide","status":"publish","type":"news","link":"https:\/\/prismbiolab.com\/ja\/news\/new-study-by-prism-biolab-demonstrates-rational-design-of-small-molecule-inhibitors-of-ctla-4-and-b7-1-protein-protein-interaction-utilizing-only-a-sequence-of-a-binding-peptide\/","title":{"rendered":"\u30b5\u30a4\u30af\u30ea\u30c3\u30af\u30da\u30d7\u30c1\u30c9\u6a21\u5023\u6280\u8853\u3092\u7528\u3044\u305fCTLA-4\u3068B7-\uff11\u306ePPI\u963b\u5bb3\u5264\u5275\u51fa\u306b\u95a2\u3059\u308b\u8ad6\u6587\u304c\u3001Pharmaceuticals\u306ePPI\u7279\u96c6\u53f7\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f"},"content":{"rendered":"<p data-renderer-start-pos=\"322\" class=\"translation-block\">\u30da\u30d7\u30c1\u30c9\u963b\u5bb3\u5264\u306e\u914d\u5217\u60c5\u5831\u304b\u3089\u4f4e\u5206\u5b50PPI (Protein-Protein Interaction) \u963b\u5bb3\u5264\u3092\u898b\u51fa\u3059\u65b0\u3057\u3044\u624b\u6cd5\u306b\u3064\u3044\u3066\u3001Pharmaceuticals\u306ePPI\u7279\u96c6\u53f7\u201cSmall Molecules Targeting Protein-Protein Interactions (PPIs): Current Strategies for the Development of New Drugs\u201d\u3067\u8ad6\u6587\u767a\u8868\u3044\u305f\u3057\u307e\u3057\u305f\u3002\n\n\u30da\u30d7\u30c1\u30c9\u963b\u5bb3\u5264\u306f\u69d8\u3005\u306a\u65b9\u6cd5\u3067\u5275\u51fa\u3067\u304d\u307e\u3059\u304c\u3001in vivo \u3067\u306e\u85ac\u7269\u52d5\u614b\u7279\u6027\u304c\u4f4e\u3044\u3053\u3068\u304b\u3089\u85ac\u7269\u3068\u3057\u3066\u958b\u767a\u3059\u308b\u3053\u3068\u306b\u306f\u56f0\u96e3\u3092\u4f34\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001\u4f4e\u5206\u5b50\u5316\u5408\u7269\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u306eHTS\u304b\u3089PPI\u963b\u5bb3\u5264\u3092\u898b\u51fa\u3059\u3053\u3068\u3082\u56f0\u96e3\u3067\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30da\u30d7\u30c1\u30c9\u963b\u5bb3\u5264\u306e\u60c5\u5831\u304b\u3089\u4f4e\u5206\u5b50\u963b\u5bb3\u5264\u3092\u8a2d\u8a08\u3059\u308b\u6280\u8853\u306f\u3001PPI\u306a\u3069\u306e\u201dundruggable target\u201d\u306b\u5bfe\u3057\u3066\u7279\u306b\u6709\u7528\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\n\n\u672c\u8ad6\u6587\u3067\u306f\u3001\u5f0a\u793e\u306ePepMetics\u6280\u8853\u3092\u5229\u7528\u3057\u3066\u3001CTLA-4\u3068B7-1\u306ePPI\u306b\u5bfe\u3059\u308b\u4f4e\u5206\u5b50\u963b\u5bb3\u5264\u3092\u5275\u51fa\u3059\u308b\u624b\u6cd5\u306b\u3064\u3044\u3066\u8ff0\u3079\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u74b0\u72b6\u30da\u30d7\u30c1\u30c9\u963b\u5bb3\u5264\u306e\u914d\u5217\u60c5\u5831\u306e\u307f\u3092\u5229\u7528\u3057\u3066\u3001\u30da\u30d7\u30c1\u30c9\u306e\u9023\u7d9a\u30a2\u30df\u30ce\u9178\u3092\u6a21\u5023\u3059\u308b\u4e00\u9023\u306ePepMetics\u5206\u5b50\u3092\u30c7\u30b6\u30a4\u30f3\u3057\u5408\u6210\u3057\u3001\u4f4e\u5206\u5b50PPI\u963b\u5bb3\u5264\u3092\u8fc5\u901f\u306b\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u6a19\u7684\u86cb\u767d\u8cea\u306b\u7d50\u5408\u3057\u305f\u30da\u30d7\u30c1\u30c9\u306eX\u7dda\u69cb\u9020\u3092\u5fc5\u8981\u3068\u305b\u305a\u306b\u3001\u30da\u30d7\u30c1\u30c9\u963b\u5bb3\u5264\u304b\u3089\u4f4e\u5206\u5b50\u963b\u5bb3\u5264\u3092\u8a2d\u8a08\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u672c\u624b\u6cd5\u306f\u30b8\u30fc\u30f3\u30d5\u30ed\u30f3\u30c6\u30a3\u30a2\u682a\u5f0f\u4f1a\u793e1\u304a\u3088\u3073\u7406\u8ad6\u5275\u85ac\u7814\u7a76\u62402\u3068\u306e\u5171\u540c\u3067\u958b\u767a\u3055\u308c\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n<p data-renderer-start-pos=\"1977\"><a href=\"https:\/\/doi.org\/10.3390\/ph15121506\" target=\"_blank\" rel=\"noopener\">Rational Strategy for Designing Peptidomimetic Small Molecules Based on Cyclic Peptides Targeting Protein\u2013Protein Interaction between CTLA-4 and B7-1<\/a><\/p>\n<p data-renderer-start-pos=\"2128\">Pharmaceuticals 2022, 15(12), 1506<\/p>\n<p data-renderer-start-pos=\"2168\"><sup data-renderer-mark=\"true\">1. <span data-inline-card=\"true\" data-card-url=\"https:\/\/www.genefrontier.com\/en\/?noredirect=en_US\"><span class=\"loader-wrapper\"><span aria-expanded=\"false\" aria-haspopup=\"true\"><a class=\"css-1n28348 eeajecn1\" tabindex=\"0\" role=\"button\" href=\"https:\/\/www.genefrontier.com\/en\/?noredirect=en_US\" target=\"_blank\" rel=\"noopener\" data-testid=\"inline-card-resolved-view\"><span class=\"css-1h3cbh4 e158gagu6\"><span class=\"css-sowgxi e158gagu2\"><img loading=\"lazy\" decoding=\"async\" class=\"smart-link-icon css-qg49p3 e1bjtjov2 alignnone\" src=\"https:\/\/www.genefrontier.com\/images\/favicon.ico\" alt=\"\" width=\"48\" height=\"48\" data-testid=\"inline-card-icon-and-title-image\" \/><\/span><span class=\"smart-link-title-wrapper css-0 e158gagu0\">\u30b8\u30fc\u30f3\u30d5\u30ed\u30f3\u30c6\u30a3\u30a2\u682a\u5f0f\u4f1a\u793e<\/span><\/span><\/a><\/span><\/span><\/span>\u00a0<\/sup><\/p>\n<p data-renderer-start-pos=\"2174\"><sup data-renderer-mark=\"true\">2\u00a0<\/sup> <a class=\"css-1rn59kg\" title=\"http:\/\/www.itmol.com\/\" href=\"http:\/\/www.itmol.com\/\" target=\"_blank\" rel=\"noopener\" data-renderer-mark=\"true\">http:\/\/www.itmol.com\/<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>The paper published in the special issue of Pharmaceuticals journal dedicated to \u201cSmall Molecules Targeting Protein-Protein Interactions (PPIs): Current Strategies for the Development of New Drugs\u201d presents a new method to generate small-molecules PPI inhibitors using only a sequence of a binding peptide. Potent and active PPI inhibitor peptides can be readily generated by various [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","tags":[],"news-category":[8],"class_list":["post-1645","news","type-news","status-publish","hentry","news-category-news","post"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New study by PRISM Biolab demonstrates rational design of small molecule inhibitors of CTLA-4 and B7-1 protein-protein interaction utilizing only a sequence of a binding peptide - PRISM BioLab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/prismbiolab.com\/ja\/news\/new-study-by-prism-biolab-demonstrates-rational-design-of-small-molecule-inhibitors-of-ctla-4-and-b7-1-protein-protein-interaction-utilizing-only-a-sequence-of-a-binding-peptide\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New study by PRISM Biolab demonstrates rational design of small molecule inhibitors of CTLA-4 and B7-1 protein-protein interaction utilizing only a sequence of a binding peptide - PRISM BioLab\" \/>\n<meta property=\"og:description\" content=\"The paper published in the special issue of Pharmaceuticals journal dedicated to \u201cSmall Molecules Targeting Protein-Protein Interactions (PPIs): Current Strategies for the Development of New Drugs\u201d presents a new method to generate small-molecules PPI inhibitors using only a sequence of a binding peptide. Potent and active PPI inhibitor peptides can be readily generated by various [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/prismbiolab.com\/ja\/news\/new-study-by-prism-biolab-demonstrates-rational-design-of-small-molecule-inhibitors-of-ctla-4-and-b7-1-protein-protein-interaction-utilizing-only-a-sequence-of-a-binding-peptide\/\" \/>\n<meta property=\"og:site_name\" content=\"PRISM BioLab\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-18T09:46:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/prismbiolab.com\/wp-content\/uploads\/2022\/08\/career-collage.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"1122\" \/>\n\t<meta property=\"og:image:height\" content=\"1097\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/prismbiolab.com\/wp-content\/uploads\/2022\/08\/career-collage.jpeg\" \/>\n<meta name=\"twitter:label1\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data1\" content=\"1\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/prismbiolab.com\\\/news\\\/new-study-by-prism-biolab-demonstrates-rational-design-of-small-molecule-inhibitors-of-ctla-4-and-b7-1-protein-protein-interaction-utilizing-only-a-sequence-of-a-binding-peptide\\\/\",\"url\":\"https:\\\/\\\/prismbiolab.com\\\/news\\\/new-study-by-prism-biolab-demonstrates-rational-design-of-small-molecule-inhibitors-of-ctla-4-and-b7-1-protein-protein-interaction-utilizing-only-a-sequence-of-a-binding-peptide\\\/\",\"name\":\"New study by PRISM Biolab demonstrates rational design of small molecule inhibitors of CTLA-4 and B7-1 protein-protein interaction utilizing only a sequence of a binding peptide - 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