{"id":1368,"date":"2021-11-02T04:59:43","date_gmt":"2021-11-02T04:59:43","guid":{"rendered":"https:\/\/prismbiolab.com\/?page_id=1368"},"modified":"2021-11-02T05:00:50","modified_gmt":"2021-11-02T05:00:50","slug":"test-structure-based-drug-design","status":"publish","type":"page","link":"https:\/\/prismbiolab.com\/ja\/test-structure-based-drug-design\/","title":{"rendered":"Test Structure-Based Drug Design"},"content":{"rendered":"
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PepMetics\u2122\u306f\u3001\u72ec\u81ea\u306e\u6a21\u5023\u9aa8\u683c\u3092\u7528\u3044\u305fStructure-Based Drug Design (SBDD\uff09\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059\u3002<\/p>\n

\u5f93\u6765\u306eSBDD\u3067\u306f\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u86cb\u767d\u306e\u30dd\u30b1\u30c3\u30c8\u306e\u7d50\u5408\u90e8\u4f4d\u306b\u5408\u308f\u305b\u3066\u30d5\u30a1\u30fc\u30de\u30b3\u30d5\u30a9\u30a2\u3092\u8a2d\u5b9a\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001PepMetics\u3067\u306f\u3001\u30ea\u30ac\u30f3\u30c9\u30da\u30d7\u30c1\u30c9\u306e\u9aa8\u683c\u69cb\u9020\u3092\u6a21\u5023\u3057\u305f\u72ec\u81ea\u306e\u9aa8\u683c\u3092\u898b\u3064\u3051\u51fa\u3057\u3001\u5bfe\u5fdc\u3059\u308b\u30ea\u30ac\u30f3\u30c9\u306e\u30a2\u30df\u30ce\u9178\u5074\u9396\u3092\u4ed8\u3051\u308b\u3053\u3068\u3067\u6a21\u5023\u5316\u5408\u7269\u3092\u5408\u6210\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/h3>\n

The more than forty scaffolds included in the PepMetics Library covers a wide range of helical structures such as a standard, bent, or partially unfolded helix (i.e. represented by the red area in the graphic below). Each scaffold covers a specific area of the helix, ultimately replicating the necessary structure of a natural helix.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>

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\n\t\t\t\n\t\t\t\"\"\n\t\t\t<\/a><\/div>\n\n<\/div><\/div><\/div>
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\u56f3\u306f\u3001\u5074\u9396\u306eC\u03b1-C\u03b2\u7d50\u5408\u89e3\u6790\u306b\u57fa\u3065\u3044\u3066\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u62bd\u51fa\u3057\u305f\u30da\u30d7\u30c1\u30c9\u69cb\u9020\u306e\u5316\u5b66\u7a7a\u9593\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u8d64\u3068\u7dd1\u306e\u70b9\u306f\u3001\u305d\u308c\u305e\u308c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u03b1-\u30d8\u30ea\u30c3\u30af\u30b9\u69cb\u9020\u3068\u03b2-\u30b7\u30fc\u30c8\u69cb\u9020\u306e\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u5206\u5e03\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002\u9ed2\u3044\u70b9\u306f\u3001PepMetics\u306e\u9aa8\u683c\u304c\u53d6\u308a\u5f97\u308b\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u3067\u3042\u308a\u3001\u30d8\u30ea\u30c3\u30af\u30b9\u9818\u57df\u306b\u91cd\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u3053\u306e\u9aa8\u683c\u304c\u03b1-\u30d8\u30ea\u30c3\u30af\u30b9\u69cb\u9020\u3092\u6b63\u78ba\u306b\u6a21\u5023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002 <\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>

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\n\t\t\t\n\t\t\t\"\"\n\t\t\t<\/a><\/div>\n\n<\/div><\/div><\/div>
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\u9ed2\u3044\u70b9\u304c\u5e83\u304f\u5206\u5e03\u3057\u3066\u3044\u308b\u5834\u5408\u306f\u3001\u30a8\u30f3\u30c8\u30ed\u30d4\u30fc\u640d\u5931\u306b\u3088\u3063\u3066\u5316\u5408\u7269\u306e\u7d50\u5408\u80fd\u529b\u304c\u640d\u306a\u308f\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u307e\u3059\u3002\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u30ea\u30ac\u30f3\u30c9\u306e\u5f62\u72b6\u3068\u8fd1\u3044\u4f4d\u7f6e\u306b\u3042\u308b\u5834\u5408\u3001\u305d\u306e\u9aa8\u683c\u306f\u30ea\u30ac\u30f3\u30c9\u306e\u5f62\u72b6\u306e\u6a21\u5023\u5ea6\u304c\u9ad8\u304f\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u5bfe\u3057\u3066\u5f37\u304f\u7d50\u5408\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002
\nPRISM\u793e\u306e\u9aa8\u683c\u306f\u3001\u305d\u308c\u305e\u308c\u7279\u5b9a\u306e\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u3092\u6301\u3061\u3001\u72ed\u3044\u7279\u5b9a\u306e\u7bc4\u56f2\u3092\u30ab\u30d0\u30fc\u3057\u3066\u3044\u307e\u3059\u3002PepMetics\u306e18\u500b\u306e\u9aa8\u683c\u3092\u5408\u308f\u305b\u308b\u3068\u3001\u30d8\u30ea\u30c3\u30af\u30b9\u306e\u7a7a\u9593\u5168\u4f53\u3092\u30ab\u30d0\u30fc\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u30ea\u30ac\u30f3\u30c9\u306e\u69cb\u9020\u306b\u9069\u3057\u305f\u9aa8\u683c\u306e\u9078\u629e\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>

\u4e0a\u8a18\u306e\u5206\u6790\u306b\u3088\u308a\u3001PepMetic\u5316\u5408\u7269\u304c\u4ed6\u306e\u9aa8\u683c\u6a21\u5023\u5316\u5408\u7269\u306b\u5bfe\u3057\u3066\u512a\u4f4d\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/h3>\n
\n\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

PepMetics\u2122 Technology enables the Scaffold Mimetic Approach for Structure-Based Drug Design (SBDD). While conventional SBDD uses pharmacophores to fit into the binding site of the partner pocket, PepMetics can mimic the scaffold structure of the ligand peptide and attach corresponding amino acid side chains of the ligand. The more than forty scaffolds included in the […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1368","page","type-page","status-publish","hentry","post"],"yoast_head":"\nTest Structure-Based Drug Design - PRISM BioLab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/prismbiolab.com\/ja\/test-structure-based-drug-design\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Test Structure-Based Drug Design - PRISM BioLab\" \/>\n<meta property=\"og:description\" content=\"PepMetics\u2122 Technology enables the Scaffold Mimetic Approach for Structure-Based Drug Design (SBDD). While conventional SBDD uses pharmacophores to fit into the binding site of the partner pocket, PepMetics can mimic the scaffold structure of the ligand peptide and attach corresponding amino acid side chains of the ligand. 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