{"id":148,"date":"2021-09-01T11:11:03","date_gmt":"2021-09-01T11:11:03","guid":{"rendered":"https:\/\/prismbiolab.com\/?page_id=148"},"modified":"2022-01-05T04:29:04","modified_gmt":"2022-01-05T09:29:04","slug":"sequence-mimetics-cyclic-stapled-peptides","status":"publish","type":"page","link":"https:\/\/prismbiolab.com\/ja\/technology\/sequence-mimetics-cyclic-stapled-peptides\/","title":{"rendered":"\u914d\u5217\u306b\u57fa\u3065\u304f\u5275\u85ac"},"content":{"rendered":"
\n
\n\t

\u7d50\u5408\u69cb\u9020\u306e\u89e3\u660e\u306f\u3001Structure-Based Drug Design\u306e\u5fc5\u9808\u8981\u7d20\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u74b0\u72b6\u30da\u30d7\u30c1\u30c9\u306e\u3088\u3046\u306a\u30da\u30d7\u30c1\u30c9\u30d0\u30a4\u30f3\u30c0\u30fc\u306e\u591a\u304f\u306f\u3001X\u7dda\u69cb\u9020\u89e3\u6790\u306a\u3069\u306b\u3088\u308b\u7d50\u5408\u69cb\u9020\u306e\u89e3\u660e\u306f\u56f0\u96e3\u3067\u3059\u3002<\/p>\n

The following is the process that PepMetics\u00ae<\/sup> Technology follows to generate hit compounds:<\/p>\n

    \n
  1. \u74b0\u72b6\u30da\u30d7\u30c1\u30c9\u306e\u7d50\u5408\u90e8\u4f4d\u306f\u03b1-\u30d8\u30ea\u30c3\u30af\u30b9\u3001\u03b2-\u30bf\u30fc\u30f3\u306b\u4f3c\u305f\u69cb\u9020\u3092\u3068\u308b\u3053\u3068\u304c\u591a\u3044\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n
  2. \u74b0\u72b6\u30da\u30d7\u30c1\u30c9\u306e\u4e00\u90e8\u304c\u03b1-\u30d8\u30ea\u30c3\u30af\u30b9\u307e\u305f\u306f\u03b2-\u30bf\u30fc\u30f3\u306e\u3044\u305a\u308c\u304b\u3092\u5f62\u6210\u3057\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u306e\u7d50\u5408\u306b\u95a2\u4e0e\u3059\u308b\u3068\u4eee\u5b9a\u3057\u307e\u3059\u3002<\/li>\n
  3. 3\u3064\u306e\u9023\u7d9a\u3057\u305f\u30a2\u30df\u30ce\u9178\u30921\u3064\u305a\u3064\u305a\u3089\u3057\u3066\u3001\u74b0\u72b6\u30da\u30d7\u30c1\u30c9\u306e\u914d\u5217\u306e\u4e00\u90e8\u3092\u6a21\u5023\u3057\u305fPepMetics\u5316\u5408\u7269\u3092\u5408\u6210\u3057\u307e\u3059\u3002<\/li>\n
  4. PepMetics \u5316\u5408\u7269\u306e\u6d3b\u6027\u3092\u8a55\u4fa1\u3057\u3001\u6700\u521d\u306e\u30d2\u30c3\u30c8\u5316\u5408\u7269\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u30d2\u30c3\u30c8\u5316\u5408\u7269\u306f\u3001\u7d50\u5408\u306b\u95a2\u4e0e\u3059\u308b\u30a2\u30df\u30ce\u9178\u914d\u5217\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n
  5. \u5f97\u3089\u308c\u305f\u30d2\u30c3\u30c8\u5316\u5408\u7269\u306e\u7d50\u5408\u69d8\u5f0f\u3092in silico\u306e\u30c9\u30c3\u30ad\u30f3\u30b0\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3067\u4e88\u6e2c\u3057\u3001\u69cb\u9020\u6d3b\u6027\u76f8\u95a2\uff08SAR\uff09\u3092\u78ba\u8a8d\u3057\u307e\u3059\u3002<\/li>\n
  6. \u4e88\u6e2c\u3055\u308c\u305f\u7d50\u5408\u69d8\u5f0f\u306e\u30d5\u30a1\u30fc\u30de\u30b3\u30d5\u30a9\u30a2\u306b\u57fa\u3065\u3044\u3066\u3001\u3055\u3089\u306b\u30d0\u30fc\u30c1\u30e3\u30eb\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3044\u3001\u6709\u671b\u306a\u5316\u5408\u7269\u3092\u5b9f\u969b\u306b\u5408\u6210\u3059\u308b\u3053\u3068\u3067\u8fc5\u901f\u306a\u6d3b\u6027\u5411\u4e0a\u304c\u53ef\u80fd\u3067\u3059\u3002<\/li>\n<\/ol>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>
    \n
    \n\t\t\t\n\t\t\t\"\"\n\t\t\t<\/a><\/div>\n\n<\/div><\/div><\/div>
    \n
    \n\t\t\t\n\t\t\t\"\"\n\t\t\t<\/a><\/div>\n\n<\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

    Effective binding structures are an essential element of Structure-Based Drug Design. However, it can be challenging to obtain effective binding structures with peptide binders alone, such as cyclic peptides. The following is the process that PepMetics\u00ae Technology follows to generate hit compounds: Cyclic peptides often have the \u03b1-helix, \u03b2-turn or a similar structure; Assume a […]<\/p>\n","protected":false},"author":3,"featured_media":590,"parent":21,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-148","page","type-page","status-publish","has-post-thumbnail","hentry","post"],"yoast_head":"\nSequence Mimetics: Cyclic & Stapled Peptides - PRISM BioLab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/prismbiolab.com\/ja\/technology\/sequence-mimetics-cyclic-stapled-peptides\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sequence Mimetics: Cyclic & Stapled Peptides - PRISM BioLab\" \/>\n<meta property=\"og:description\" content=\"Effective binding structures are an essential element of Structure-Based Drug Design. However, it can be challenging to obtain effective binding structures with peptide binders alone, such as cyclic peptides. 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