{"id":1505,"date":"2022-10-17T11:39:46","date_gmt":"2022-10-17T15:39:46","guid":{"rendered":"https:\/\/prismbiolab.com\/?page_id=1505"},"modified":"2026-02-07T04:49:14","modified_gmt":"2026-02-06T19:49:14","slug":"blog","status":"publish","type":"page","link":"https:\/\/prismbiolab.com\/ja\/blog\/","title":{"rendered":"PRISM BioLab Blog – PPI Pursuit"},"content":{"rendered":"
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Insights from Evaluation of AI-driven Drug Discovery Until 2023 in Clinical Trials<\/a><\/h2>\n\t\t\t\t\t\t\t
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Application of artificial intelligence (AI) in drug discovery and development is a worldwide trend in this era. Many startups emerged since the advent of the fourth generation of AI and its extensive and rigorous developments. Even a small startup could reach a candidate in a couple of years and AI-discovered molecules have been brought into...<\/p>\t\t

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Prostate Cancer and Radiopharmaceuticals of 177Lu, 225Ac and 213Bi<\/a><\/h2>\n\t\t\t\t\t\t\t
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Prostate-specific membrane antigen (PSMA) is a promising target to achieve a selective delivery to prostate cancer.1) Even though its significance in cancer pharmacology is scarce, radiopharmaceuticals have been taken it as the target for the therapy and diagnostic purposes. PSMA targeting is the legendary story of radiopharmaceutical discovery and development and it is of high...<\/p>\t\t

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Hit to Lead in silico: Difference from Lead Optimization and AILDE Approach<\/a><\/h2>\n\t\t\t\t\t\t\t
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Hit to lead is an essential stage for the discovery of drug leads of definite properties with high probability of expanding the chemical and PK\/PD nature. As a leopard cannot change its spot, it is a must to hit the stone bridge and cross it toward the following lead optimization stage. Otherwise, you would hit...<\/p>\t\t

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Condensation Reagents for Peptide\/Amide Bonds: Still Under Development<\/a><\/h2>\n\t\t\t\t\t\t\t
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This post is related to chemistry issues related to peptide\/amide bond formation. Do you have trouble in choosing condensation reaction conditions? It is always an annoying issue to optimize condensation reagents and conditions, especially in peptide synthesis. You would have much better performance If there is a way for selecting an optimal reagent among numerous...<\/p>\t\t

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Conformational Selection or Induced Fit? Complexity of Macromolecule Interactions<\/a><\/h2>\n\t\t\t\t\t\t\t
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Complexation of a protein and the ligand induces biological functions and hence its control is the key for drug discovery. X-ray crystallography can determine the static structure in an atom-level resolution, but the dynamic conformational change as well as a small local fluctuation makes it difficult to rationally design the best ligand for a particular...<\/p>\t\t

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Current State of in silico Target fishing<\/a><\/h2>\n\t\t\t\t\t\t\t
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Drug discovery commences with careful selection of a target related to diseases. One of the golden standard schemes is library screening against the target of interest to find hit compound, elaboration to produce a lead compound, and lead optimization to give birth to the candidate. During the drug discovery and development process, off-target effects need...<\/p>\t\t

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Chemical Synthesis Paradigm Shift from Intuition to Unmanned System<\/a><\/h2>\n\t\t\t\t\t\t\t
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Chemical synthesis has long been fully dependent on intuition of talented chemists. The cycle of synthesis planning, running experiments and data analysis is the state-of-the-art chemical synthesis research process. This paradigm could be replaced by robotics and machine learning (ML). Unmanned chemical system, or cyber-physical system (CPS), is an emerging paradigm that can automated for...<\/p>\t\t

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Structure Database and Dynamics: Insight from Analysis of Cambridge Structural Database<\/a><\/h2>\n\t\t\t\t\t\t\t
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Application of big data in science database stimulates our mind to give rise to a novel idea for scientific discovery. Today is the age of data science and numerous public and commercial databases being available and the entries of data are swelling alongside the supporting information related to the main topic. As an approach to...<\/p>\t\t

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Lipopepidomimetics as Inhibitor of Protein-protein Interactions: The Case of Med25<\/a><\/h2>\n\t\t\t\t\t\t\t
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A lipopeptidomimetics is conceptually interesting mimetics of peptides for modulation of protein-protein interactions (PPIs). Lipopeptidomimetics are the mimic of lipopeptides and\/or derivatives of peptidomimetics with a fatty acid residue. A lipopeptide is a class of molecule with a structure of a peptide connected to a fatty acid. It\u2019s abundant in microbes and its amphiphilic nature...<\/p>\t\t

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Ternary Complex Design for Modulating Protein-Protein Interactions<\/a><\/h2>\n\t\t\t\t\t\t\t
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Protein-protein interaction (PPIs)-targeted drug discovery program can accommodate multiple strategies through direct interference, stabilization and indirect modulations, Ternary complex design is an emerging approach of mimicking biological process and recognition machinery by a monovalent \u201cmolecular glue\u201d or a bivalent small molecule.1) Since the appearance of PPI inhibitors in 20042) and its evolution to clinical trials...<\/p>\t\t

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