{"id":151,"date":"2021-09-01T11:11:32","date_gmt":"2021-09-01T11:11:32","guid":{"rendered":"https:\/\/prismbiolab.com\/?page_id=151"},"modified":"2022-01-05T09:53:59","modified_gmt":"2022-01-05T14:53:59","slug":"structure-based-drug-design","status":"publish","type":"page","link":"https:\/\/prismbiolab.com\/ja\/technology\/structure-based-drug-design\/","title":{"rendered":"\u69cb\u9020\u306b\u57fa\u3065\u304f\u5275\u85ac"},"content":{"rendered":"
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PepMetics\u00ae<\/sup> \u306f\u3001\u72ec\u81ea\u306e\u6a21\u5023\u9aa8\u683c\u3092\u7528\u3044\u305fStructure-Based Drug Design (SBDD\uff09\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059\u3002<\/p>\n

\u5f93\u6765\u306eSBDD\u3067\u306f\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u86cb\u767d\u306e\u30dd\u30b1\u30c3\u30c8\u306e\u7d50\u5408\u90e8\u4f4d\u306b\u5408\u308f\u305b\u3066\u30d5\u30a1\u30fc\u30de\u30b3\u30d5\u30a9\u30a2\u3092\u8a2d\u5b9a\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001PepMetics\u3067\u306f\u3001\u30ea\u30ac\u30f3\u30c9\u30da\u30d7\u30c1\u30c9\u306e\u9aa8\u683c\u69cb\u9020\u3092\u6a21\u5023\u3057\u305f\u72ec\u81ea\u306e\u9aa8\u683c\u3092\u898b\u3064\u3051\u51fa\u3057\u3001\u5bfe\u5fdc\u3059\u308b\u30ea\u30ac\u30f3\u30c9\u306e\u30a2\u30df\u30ce\u9178\u5074\u9396\u3092\u4ed8\u3051\u308b\u3053\u3068\u3067\u6a21\u5023\u5316\u5408\u7269\u3092\u5408\u6210\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/h3>\n

PepMetics\u3067\u4f7f\u7528\u3055\u308c\u308b40\u7a2e\u985e\u4ee5\u4e0a\u306e\u9aa8\u683c\u306f\u3001\u6a19\u6e96\u7684\u306a\u30d8\u30ea\u30c3\u30af\u30b9\u3001\u5c48\u66f2\u3057\u305f\u30d8\u30ea\u30c3\u30af\u30b9\u3001\u90e8\u5206\u7684\u306b\u5c55\u958b\u3057\u305f\u30d8\u30ea\u30c3\u30af\u30b9\u306a\u3069\u3001\u69d8\u3005\u306a\u30d8\u30ea\u30c3\u30af\u30b9\u69cb\u9020\u3092\u6a21\u5023\u3057\u3066\u3044\u307e\u3059\uff08\u4e0b\u56f3\u306e\u8d64\u3044\u90e8\u5206\u3067\u8868\u3055\u308c\u3066\u3044\u307e\u3059\uff09\u3002\u5404\u9aa8\u683c\u306f\u3001\u30d8\u30ea\u30c3\u30af\u30b9\u306e\u7279\u5b9a\u306e\u9818\u57df\u3092\u30ab\u30d0\u30fc\u3057\u3001\u5168\u4f53\u3068\u3057\u3066\u3042\u3089\u3086\u308b\u5929\u7136\u306e\u30d8\u30ea\u30c3\u30af\u30b9\u3092\u6a21\u5023\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>

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\n\t\t\t\n\t\t\t\"\"\n\t\t\t<\/a><\/div>\n\n<\/div><\/div><\/div>
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\u56f3\u306f\u3001\u5074\u9396\u306eC\u03b1-C\u03b2\u7d50\u5408\u89e3\u6790\u306b\u57fa\u3065\u3044\u3066\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u62bd\u51fa\u3057\u305f\u30da\u30d7\u30c1\u30c9\u69cb\u9020\u306e\u5316\u5b66\u7a7a\u9593\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u8d64\u3068\u7dd1\u306e\u70b9\u306f\u3001\u305d\u308c\u305e\u308c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u03b1-\u30d8\u30ea\u30c3\u30af\u30b9\u69cb\u9020\u3068\u03b2-\u30b7\u30fc\u30c8\u69cb\u9020\u306e\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u5206\u5e03\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002\u9ed2\u3044\u70b9\u306f\u3001PepMetics\u306e\u9aa8\u683c\u304c\u53d6\u308a\u5f97\u308b\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u3067\u3042\u308a\u3001\u30d8\u30ea\u30c3\u30af\u30b9\u9818\u57df\u306b\u91cd\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u3053\u306e\u9aa8\u683c\u304c\u03b1-\u30d8\u30ea\u30c3\u30af\u30b9\u69cb\u9020\u3092\u6b63\u78ba\u306b\u6a21\u5023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002 <\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>

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\n\t\t\t\n\t\t\t\"\"\n\t\t\t<\/a><\/div>\n\n<\/div><\/div><\/div>
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\u9ed2\u3044\u70b9\u304c\u5e83\u304f\u5206\u5e03\u3057\u3066\u3044\u308b\u5834\u5408\u306f\u3001\u30a8\u30f3\u30c8\u30ed\u30d4\u30fc\u640d\u5931\u306b\u3088\u3063\u3066\u5316\u5408\u7269\u306e\u7d50\u5408\u80fd\u529b\u304c\u640d\u306a\u308f\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u307e\u3059\u3002\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u30ea\u30ac\u30f3\u30c9\u306e\u5f62\u72b6\u3068\u8fd1\u3044\u4f4d\u7f6e\u306b\u3042\u308b\u5834\u5408\u3001\u305d\u306e\u9aa8\u683c\u306f\u30ea\u30ac\u30f3\u30c9\u306e\u5f62\u72b6\u306e\u6a21\u5023\u5ea6\u304c\u9ad8\u304f\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u5bfe\u3057\u3066\u5f37\u304f\u7d50\u5408\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002
\nPRISM\u793e\u306e\u9aa8\u683c\u306f\u3001\u305d\u308c\u305e\u308c\u7279\u5b9a\u306e\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u3092\u6301\u3061\u3001\u72ed\u3044\u7279\u5b9a\u306e\u7bc4\u56f2\u3092\u30ab\u30d0\u30fc\u3057\u3066\u3044\u307e\u3059\u3002PepMetics\u306e18\u500b\u306e\u9aa8\u683c\u3092\u5408\u308f\u305b\u308b\u3068\u3001\u30d8\u30ea\u30c3\u30af\u30b9\u306e\u7a7a\u9593\u5168\u4f53\u3092\u30ab\u30d0\u30fc\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u30ea\u30ac\u30f3\u30c9\u306e\u69cb\u9020\u306b\u9069\u3057\u305f\u9aa8\u683c\u306e\u9078\u629e\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>

\u4e0a\u8a18\u306e\u5206\u6790\u306b\u3088\u308a\u3001PepMetic\u5316\u5408\u7269\u304c\u4ed6\u306e\u9aa8\u683c\u6a21\u5023\u5316\u5408\u7269\u306b\u5bfe\u3057\u3066\u512a\u4f4d\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/h3>\n
\n\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

PepMetics\u00ae Technology enables the Scaffold Mimetic Approach for Structure-Based Drug Design (SBDD). While conventional SBDD uses pharmacophores to fit into the binding site of the partner pocket, PepMetics can mimic the scaffold structure of the ligand peptide and attach corresponding amino acid side chains of the ligand. The more than forty scaffolds included in the […]<\/p>\n","protected":false},"author":3,"featured_media":590,"parent":21,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-151","page","type-page","status-publish","has-post-thumbnail","hentry","post"],"yoast_head":"\nStructure-Based Drug Design - PRISM BioLab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/prismbiolab.com\/ja\/technology\/structure-based-drug-design\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Structure-Based Drug Design - PRISM BioLab\" \/>\n<meta property=\"og:description\" content=\"PepMetics\u00ae Technology enables the Scaffold Mimetic Approach for Structure-Based Drug Design (SBDD). While conventional SBDD uses pharmacophores to fit into the binding site of the partner pocket, PepMetics can mimic the scaffold structure of the ligand peptide and attach corresponding amino acid side chains of the ligand. 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