PRISM BioLab Blog – PPI Pursuit

Application of big data in science database stimulates our mind to give rise to a novel idea for scientific discovery. Today is the age of data science and numerous public and commercial databases being available and the entries of data are swelling alongside the supporting information related to the main topic. As an approach to...

A lipopeptidomimetics is conceptually interesting mimetics of peptides for modulation of protein-protein interactions (PPIs). Lipopeptidomimetics are the mimic of lipopeptides and/or derivatives of peptidomimetics with a fatty acid residue. A lipopeptide is a class of molecule with a structure of a peptide connected to a fatty acid. It’s abundant in microbes and its amphiphilic nature...

Protein-protein interaction (PPIs)-targeted drug discovery program can accommodate multiple strategies through direct interference, stabilization and indirect modulations, Ternary complex design is an emerging approach of mimicking biological process and recognition machinery by a monovalent “molecular glue” or a bivalent small molecule.1) Since the appearance of PPI inhibitors in 20042) and its evolution to clinical trials...

Molecular design is a crucial process of medicinal chemistry for the generation of the candidate in drug discovery and development. The approaches for the design of the next set of molecules for SAR have been developed for long: structure-based drug design and molecular generation with AI/ML are the recent examples in terms of technologies. Conceptually...

PPI (protein-protein interaction) detection methods dramatically change through the invention of novel technology and theory. PPI detection is to elucidate and validate the presence and function of a target PPI. Even though the computational approaches are improving for PPIs prediction and the technologies are rapidly developing after the advent of deep learning,1),2) it is a...

Oral drugs diminish the stress of disease treatments. Oral bioavailability is governed by multiple parameters: membrane permeability, action of transporters, metabolism (notably the first pass effect) and so on. Cell permeability is a requisite physicochemical parameter for oral absorption. Recent advance towards the discovery of a molecular chameleon1) and innovation in analytical methods is providing...

TACnology is an emerging term in pharmaceutical science.1) Modulation of the posttranslational modification (PTM) machinery in nature enables us to control the natural biological process toward the desired direction. PROTAC (PROteolysis TArgeting Chimera) is the most popular TACnology but proteolysis is not the only target for drug design. Chimera molecule-mediated targeting of a particular biological...

Bioisosteres are useful sets of tools for medicinal chemistry so as to endow a hit or the lead to possess the requisite pharmacokinetic and pharmacodynamic property with high activity and selectivity. As discussed in our blog,1) bioisosteres of prevalent chemical structures are still developing. However, it is often the case with a medicinal chemist to...

Structure-based drug design (SBDD) is a rational and reasonable way for the creation of more feasible and acceptable molecules to the target protein of interest. Generative AI is changing our way of life, and it has a huge impact on scientists and researchers. Recent development of generative AI-mediated structure-based computational design is opening the utilization...

Prediction and selection of a ligand binding mode with high accuracy is still a difficult challenge in molecular docking even in this age of high computational capacity. Numerous challenges have been performed for over a century due to the overwhelming demand for protein-ligand complex in drug discovery. Induced fit is one of the intriguing but...