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Technology integration: From Cyclic Peptides to Small Molecules

Technology integration: From Cyclic Peptides to Small Molecules

Novel technologies and strategies bring up beautiful sprouts of innovation. In our recent paper1, a two-step strategy for designing a small molecule was demonstrated by collaboration with GeneFrontier through the integration of respective technologies. This is a fantastic example of synergy creation, leveraging each strength to develop a new and practical strategy. GeneFrontier has unique...

Targeting PPI: What’s PPI inhibitor?

PPI-targeted drug discovery strategy is intriguing field. Target identification and functional modulation are crucial for new drug discovery and development. Assay development, technological improvements of structural biology and bioinformatics allowed us to rapidly identify the target so far, even though there are still challenges. Target-based drug discovery is a current standard, and a project often...

Cyclic peptides: Not Just A Goldmine for PPI Drug Discovery

Transition from a macrocyclic peptide to a small molecule with the desired activity is still a huge challenge in drug discovery and development. Here is an interesting strategy “Peptide-to-Small Molecule” developed by Shionogi Pharma Co., Ltd., where small molecules are generated by pharmacophore-guided de novo design from macrocyclic peptides.1 Macrocyclic peptides are goldmines for drug...

PepMetics®: Our Engine for Paradigm Shifts on PPI Drug Discovery

Science has solved numerous issues relating to disease treatment through the discovery of new drugs. Small synthetic molecules, natural products, antibodies, and nucleic acids have been developed into candidates through the aid of SBDD (structure-based drug design) and HTS (high-throughput screening) approaches. Tremendous efforts have been thrown into molecular target drugs, but about 85% of...

Chemist/ Medicinal Chemist

PRISM BioLab is seeking associate level Chemist/Medicinal Chemist. The successful candidate will be responsible for design and synthesis of novel compounds to move internal and collaboration projects forward. In PRISM BioLab, based in Japan, innovative research are on-going to discover a new medicine for patients who are not ameliorated by currently existing treatments. We have...

Senior Medicinal Chemist

PRISM BioLab is seeking Senior Medicinal Chemist reporting to the Head of R&D. The successful candidate will be responsible for leading/establishing collaborations, and the state of the art technologies that drive innovative approaches for drug discovery. The candidate is also responsible for leading PRISM BioLab internal projects to move them forward to clinical applications.In PRISM...

Senior Pharmacologist

PRISM BioLab is seeking a Senior Pharmacologist reporting to the Head of R&D. The successful candidate will be responsible for leading/establishing collaborations, and the state of the art technologies that drive innovative approaches for drug discovery. The candidate is also responsible for leading PRISM BioLab internal projects to move them forward to clinical applications.In PRISM...

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