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Journal of Computational Chemistry, 42(14), 956-969 (2021)
Higo, Junichi; Takashima, Hajime; Fukunishi, Yoshifumi; Yoshimori, Atsushi
Archives: News
E7386, a selective inhibitor of the interaction between β-catenin and CBP, exerts antitumor activity in tumor models with activated canonical wnt signaling
Cancer Research, 81(4), 1052-1062 (2021)
Yamada, Kazuhiko; Hori, Yusaku; Inoue, Satoshi; Yamamoto, Yuji; Iso, Kentaro; Kamiyama, Hiroshi; Yamaguchi, Atsumi; Kimura, Takayuki; Uesugi, Mai; Ito, Junichi; Matsuki, Masahiro; Nakamoto, Kazutaka; Harada, Hitoshi; Yoneda, Naoki; Takemura, Atsushi; Kushida, Ikuo; Wakayama, Naomi; Kubara, Kenji; Kato, Yu; Semba, Taro; Yokoi, Akira; Matsukura, Masayuki; Odagami, Takenao; Iwata, Masao; Tsuruoka, Akihiko; Uenaka, Toshimitsu; Matsui, Junji; Matsushima, Tomohiro; Nomoto, Kenichi; Kouji, Hiroyuki; Owa, Takashi; Funahashi, Yasuhiro; Ozawa, Yoichi
Anti-tumor activity of the small molecule inhibitor PRI-724 against β-catenin-activated hepatocellular carcinoma
Anticancer Research, 40, 5211-5219 (2020)
Gabata, Ryosuke; Harada, Kenichi; Mizutani, Yuki; Ouchi, Hirofumi; Yoshimura, Kaori; Sato, Yasunori; Kitao, Azusa; Kimura, Kiminori; Kouji, Hiroyuki; Miyashita, Tomoharu; Tajima, Hidehiro; Ohta, Tetsuo
β-catenin signaling inhibitors ICG-001 and C-82 improve fibrosis in preclinical models of endometriosis
Scientific Reports, 9(1), 20056 (2019)
Hirakawa, Tomoko; Nasu, Kaei; Miyabe, Saori; Kouji, Hiroyuki; Katoh, Akira; Uemura, Naoto; Narahara, Hisashi
mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model
Pharmacology Biochemistry and Behavior, 176, 1-5 (2019)
Kawase, Haruki; Ago, Yukio; Naito, Megumi; Higuchi, Momoko; Hara, Yuta; Hasebe, Shigeru; Tsukada, Shinji; Kasai, Atsushi; Nakazawa, Takanobu; Mishina, Tadashi; Kouji, Hiroyuki; Takuma, Kazuhiro; Hashimoto, Hitoshi
The novel inhibitor PRI-724 for Wnt/β-catenin/CBP signaling ameliorates bleomycin-induced pulmonary fibrosis in mice
Experimental Lung Research, 45(7), 188-199 (2019)
Okazaki, Hiroyasu; Sato, Seidai; Koyama, Kazuya; Morizumi, Shun; Abe, Shuichi; Azuma, Momoyo; Chen, Yajuan; Goto, Hisatsugu; Aono, Yoshinori; Ogawa, Hirohisa; Kagawa, Kozo; Nishimura, Haruka; Kawano, Hiroshi; Toyoda, Yuko; Uehara, Hisanori; Kouji, Hiroyuki; Nishioka, Yasuhiko
A mimetic of the mSin3-binding helix of NRSF/REST ameliorates abnormal pain behavior in chronic pain models
Bioorganic and Medicinal Chemistry Letters, 27, 4705-4709 (2017)
Ueda, Hiroshi; Jun-ichi Kurita; Neyama, Hiroyuki; Hirao, Yuuka; Kouji, Hiroyuki; Mishina, Tadashi; Kasai, Masaji; Nakano, Hirofumi; Yoshimori, Atsushi; Nishimura, Yoshifumi
Establishment of an intermittent cold stress model using Tupaia Belangeri and evaluation of compound C737 targeting neuron-restrictive silencer factor
Experimental Animals, 65(3), 285-292 (2016)
Hai-Ying, Chi; Nagano, Kiori; Ezzikouri, Sayeh; Yamaguchi, Chiho; Kayesh, Mohammad Enamul Hoque; Rebbani, Khadija; Kitab, Bouchra; Nakano, Hirohumi; Kouji, Hiroyuki; Kohara, Michinori; Tsukiyama-Kohara, Kyoko
Follow-up: Prospective compound design using the ‘SAR Matrix’ method and matrix-derived conditional probabilities of activity
F1000Research, 4, 75 (2015)
Gupta-Ostermann, Disha; Hirose, Yoichiro; Odagami, Takenao; Kouji, Hiroyuki; Bajorath, Jurgen
Three-dimensional structural diversity-oriented peptidomimetics based on the cyclopropylic strain
Organic Letters, 15(7), 1686-1689 (2013)
Mizuno, Akira; Miura, Shiho; Watanabe, Mizuki; Ito, Yoshihiko; Yamada, Shizuo; Odagami, Takenao; Kogami, Yuji; Arisawa, Mitsuhiro; Shuto, Satoshi