A Foundational Platform
for Accelerating PPI Drug Discover
The PepMetics® Library is a multidimensional matrix library constructed using the PepMetics® drug discovery platform, in which molecular scaffolds and multiple side chains are systematically varied. This library enables rapid and efficient evaluation of peptide-mimetic compounds against diverse PPI targets.
Layered Structure of the PepMetics® Library
The PepMetics® compound library consists of three layers:
Real Library
Physically stored compounds available for immediate evaluation
On-demand Library
Compounds rapidly synthesized from available intermediates or fragments
Virtual Library
Approximately 250 million theoretically accessible compounds
generated by combining established scaffolds and existing side chains, suitable for virtual screening
Natural Product–Like Chemical Space
PepMetics® technology is inspired by nature, enabling applications in PPI drug discovery through the control of molecular interactions that were previously unattainable with conventional small molecules. While traditional screening libraries occupy chemical space associated with synthetic small-molecule drugs, PepMetics® compounds reside closer to natural product-derived chemical space.
PepMetics® library compounds typically have molecular weights exceeding 500 and are characterized by high sp³ carbon content, conferring three-dimensionality, flexibility, and structural diversity. Despite their higher molecular weight, peptide bonds are eliminated from the scaffold, and hydrogen bond donors are minimized, enabling favorable oral bioavailability. These properties allow identification of hit compounds for challenging targets that are difficult to address by conventional high-throughput screening. As a foundational platform for hit generation in the early stages of drug discovery programs, the PepMetics® compound library will continue to be expanded.
